For Option-Buying/Selling strategies it is required to activate the strategy regardless of the weekdays selected for triggering it.
For Trading View strategies it is not required to activate as the strategy gets triggered via the alert from Trading View.
There is only one issue with Zerodha which is related to hedging for margin benefits. In case you have a hedging strategy then put a delay of 10 secs only on the selling legs to get the margin benefit otherwise you may run into margin issues.
Above are my personal observations only !!.